American Society of Microbiology ABMM Exam : ABMM

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American Society of Microbiology ABMM Exam Syllabus Topics:

American Society of Microbiology ABMM Sample Questions:

1. A patient with recent abdominal surgery develops a fever, abdominal pain, and a wound infection. Gram stain of the wound exudate reveals a mixture of Gram-negative rods and Gram-positivebacilli. Anaerobic culture yields a foul-smelling, Gram-negative rod that is bile-esculin positive. The MOST likely organism is:

A) Escherichia coli
B) Clostridium perfringens
C) Bacteroides fragilis
D) Peptostreptococcus anaerobius

2. Which serological marker pattern is most consistent with chronic Hepatitis B virus infection with high infectivity?

A) HBsAg (+), Anti-HBs (-), Anti-HBc Total (+), IgM Anti-HBc (-), HBeAg (+), Anti-HBe (-)
B) HBsAg (-), Anti-HBs (+), Anti-HBc Total (+), IgM Anti-HBc (-), HBeAg (-), Anti-HBe (+)
C) HBsAg (+), Anti-HBs (-), Anti-HBc Total (+), IgM Anti-HBc (+), HBeAg (+), Anti-HBe (-)
D) HBsAg (-), Anti-HBs (+), Anti-HBc Total (-), IgM Anti-HBc (-), HBeAg (-), Anti-HBe (-)

3. During a community outbreak of influenza, a public health laboratory performs rapid antigen testing on nasopharyngeal swabs. A test for influenza A is positive, but the influenza B test is negative. Subsequently, RT-PCR is performed on the same sample, and it is negative for both influenza A and B viral RNA. The MOST likely explanation for this discordant result is:

A) The rapid antigen test has low sensitivity, resulting in a false positive.
B) The patient was infected with a novel influenza strain not detected by either assay.
C) The RT-PCR assay has a high limit of detection, missing a low viral load.
D) The rapid antigen test yielded a false positive result, and the RT-PCR was a true negative.

4. The primary mechanism of action of aminoglycoside antibiotics, such as gentamicin, involves:

A) Disruption of bacterial cell membrane integrity
B) Inhibition of bacterial protein synthesis by binding to the 30S ribosomal subunit
C) Inhibition of bacterial cell wall synthesis by binding to penicillin-binding proteins
D) Inhibition of bacterial DNA gyrase and topoisomerase IV

5. A clinical microbiology laboratory is performing antimicrobial susceptibility testing on a Streptococcus pneumoniae isolate recovered from a patient with meningitis. The isolate shows reduced susceptibility to penicillin (MIC = 2 µg/mL). The MOST likely mechanism for this reduced susceptibility is:

A) Increased activity of efflux pumps that actively remove penicillin from the cell.
B) Production of beta-lactamase enzymes that hydrolyze penicillin.
C) Modification of the peptidoglycan structure, preventing penicillin binding.
D) Alterations in the penicillin-binding proteins (PBPs) that reduce their affinity for penicillin.

Solutions: